905232

(S,R,S)-AHPC-C₆-PEG₃-butyl amine hydrochloride

≥95%

• Sinônimo(s): (2S,4R)-1-((S)-22-Amino-2-(tert-butyl)-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-NH2 HCl salt, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate
• Fórmula empírica (Notação de Hill): C₃₈H₆₁N₅O₇S · xHCl
• Peso molecular: 731.99 (free base basis)
• Número MDL: MFCD32851658
• Código UNSPSC: 12352101
• NACRES: NA.22

Propriedades

• ligand: VH032
• Ensaio: ≥95%
• Formulário: powder or crystals
• adequação da reação: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• grupo funcional: amine
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O.Cl
• InChI: 1S/C38H61N5O7S.ClH/c1-28-34(51-27-41-28)30-15-13-29(14-16-30)25-40-36(46)32-24-31(44)26-43(32)37(47)35(38(2,3)4)42-33(45)12-8-7-11-19-49-21-23-50-22-20-48-18-10-6-5-9-17-39;/h13-16,27,31-32,35,44H,5-12,17-26,39H2,1-4H3,(H,40,46)(H,42,45);1H/t31-,32+,35-;/
• chave InChI: AROZTUBYMZDNDZ-PRVWZYNMSA-N

Descrição

Aplicação

Protein degrader builiding block (S,R,S)-AHPC-C₆-PEG₃-butyl amine (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

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Outras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable