902691

Hydroxy-PEG5-t-butyl ester

• Sinônimo(s): tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Fórmula empírica (Notação de Hill): C₁₇H₃₄O₈
• Número CAS: 850090-09-4
• Peso molecular: 366.45
• Número MDL: MFCD20926402
• Código UNSPSC: 51171641

Propriedades

• Ensaio: ≥95%
• Formulário: liquid
• adequação da reação: reagent type: cross-linking reagent
• índice de refração: n/D 1.448
• densidade: 1.071
• grupo funcional: ester; hydroxyl
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Descrição

Aplicação

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Outras notas

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable