902586

Hydroxy-PEG4-t-butyl ester

• Sinônimo(s): tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate, HO-PEG4-CO-OtBu
• Fórmula empírica (Notação de Hill): C₁₅H₃₀O₇
• Número CAS: 518044-32-1
• Peso molecular: 322.39
• Código UNSPSC: 51171641
• NACRES: NA.22

Propriedades

• Ensaio: ≥95%
• forma: liquid
• adequação da reação: reagent type: cross-linking reagent
• índice de refração: n/D 1.4492
• densidade: 1.04746 g/mL
• grupo funcional: ester; hydroxyl
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
• InChI: 1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
• chave InChI: FJRDXEGYAVAMLB-UHFFFAOYSA-N

Descrição

Aplicação

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable