910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• Sinônimo(s): Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• Fórmula empírica (Notação de Hill): C₁₂H₂₃N₃O₇
• Número CAS: 217180-81-9
• Peso molecular: 321.33
• Número MDL: MFCD31561141
• Código UNSPSC: 12352106

Propriedades

• Ensaio: ≥95%
• Formulário: (Liquid or Semi-solid or Paste or Solid)
• adequação da reação: reaction type: click chemistry; reagent type: cross-linking reagent
• grupo funcional: azide; carboxylic acid
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Descrição

Aplicação

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Outras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable