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901834

Sigma-Aldrich

Pomalidomide-PEG5-Alkyne

≥95%

Sinônimo(s):

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13,16-pentaoxanonadec-18-ynamide, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader

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About This Item

Fórmula empírica (Notação de Hill):
C27H33N3O10
Peso molecular:
559.57
Número MDL:
MFCD32173795
Código UNSPSC:
51171641
NACRES:
NA.22

ligand

pomalidomide

Ensaio

≥95%

Formulário

powder or crystals

adequação da reação

reaction type: click chemistry
reagent type: ligand-linker conjugate

grupo funcional

alkyne

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCCOCCOCCOCC#C)=O)=O)NC1=O

InChI

1S/C27H33N3O10/c1-2-9-36-11-13-38-15-17-40-18-16-39-14-12-37-10-8-23(32)28-20-5-3-4-19-24(20)27(35)30(26(19)34)21-6-7-22(31)29-25(21)33/h1,3-5,21H,6-18H2,(H,28,32)(H,29,31,33)

chave InChI

RLYIVXHPIRSXJK-UHFFFAOYSA-N

Categorias relacionadas

Aplicação

Protein degrader builiding block Pomalidomide-PEG5-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

Outras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Código de classe de armazenamento

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Classe de risco de água (WGK)

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Ponto de fulgor (°F)

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Ponto de fulgor (°C)

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Certificados de análise (COA)

Lot/Batch Number
MKCG7399

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Artigos

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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