902543

Propargyl-PEG4-acid

• Sinônimo(s): 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• Fórmula empírica (Notação de Hill): C₁₂H₂₀O₆
• Número CAS: 1415800-32-6
• Peso molecular: 260.28
• Número MDL: MFCD22683284
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• Formulário: liquid
• adequação da reação: reagent type: linker
• disponibilidade: available only in USA
• índice de refração: n/D 1.460
• densidade: 1.164 g/mL
• grupo funcional: alkyne; carboxylic acid
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC(CCOCCOCCOCCOCC#C)=O
• chave InChI: WMBXAUWIPBFEOK-UHFFFAOYSA-N

Descrição

Aplicação

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Outras notas

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Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Pictogramas: GHS02
• Palavra indicadora: Danger
• Frases de perigo: H242
• Declarações de precaução: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classificações de perigo: Self-react. C
• Código de classe de armazenamento: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable