764221

Propargyl-N-hydroxysuccinimidyl ester

• Sinônimo(s): 2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate, 3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Alkyne-NHS ester, Propargyl-succinimidyl-ester
• Fórmula empírica (Notação de Hill): C₁₀H₁₁NO₅
• Número CAS: 1174157-65-3
• Peso molecular: 225.20
• Número MDL: MFCD13184973
• Código UNSPSC: 12352108
• ID de substância PubChem: 329767108
• NACRES: NA.22

Propriedades

• forma: solid
• Nível de qualidade: 100
• adequação da reação: reaction type: click chemistry; reagent type: cross-linking reagent
• pf: 36-41 °C
• grupo funcional: NHS ester; alkyne
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C#CCOCCC(ON1C(CCC1=O)=O)=O
• InChI: 1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2
• chave InChI: WKIKHHMUNOVQLD-UHFFFAOYSA-N

Descrição

Aplicação

Propargyl-N-hydroxysuccinimidyl ester may be used as a tool for identifying nucleophilic ligandable hotspots by chemoproteomic approaches.

Propargyl-NHS ester is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc, with a terminal alkyne. The alkyne can be reacted with an azide containing compound or biomolecule via copper catalyzed azide-alkyne click chemistry to yield a stable triazole linkage.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable