901566

Propargyl-PEG₂-acid

• Fórmula empírica (Notação de Hill): C₈H₁₂O₄
• Número CAS: 1859379-85-3
• Peso molecular: 172.18
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• forma: liquid
• adequação da reação: reaction type: click chemistry; reagent type: linker
• grupo funcional: alkyne; carboxylic acid
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C#CCOCCOCCC(O)=O

Descrição

Aplicação

Propargyl-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility.

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3