910058

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

≥95%

• Sinônimo(s): 2-2-6 PROTAC^® linker, Alkyne-PEG₂-acid, Bifunctional linker
• Fórmula empírica (Notação de Hill): C₁₂H₂₀O₄
• Peso molecular: 228.28
• Código UNSPSC: 12352106

Propriedades

• Ensaio: ≥95%
• Formulário: (Viscous Liquid or Semi-solid or Paste or Solid)
• adequação da reação: reaction type: click chemistry; reagent type: linker
• grupo funcional: alkyne; carboxylic acid
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OC(COCCOCCCCCCC#C)=O

Descrição

Aplicação

This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₂-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Outras notas

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable