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安全性情報

適用法令

905380

(S,R,S)-AHPC-C₆-PEG₃-butyl chloride

Name: (S,R,S)-AHPC-C6-PEG3-butyl chloride
Brand: ALDRICH

≥95%

別名:

(2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-Cl, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate

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About This Item

実験式（ヒル表記法）:

C₃₈H₅₉ClN₄O₇S

CAS番号:

1835705-55-9

分子量:

751.42

MDL番号:

MFCD31560478

UNSPSCコード:

12352101

NACRES:

NA.22

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Slide 1 of 10

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904864

(S,R,S)-AHPC-PEG₆-butyl azide

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905399

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Pomalidomide-PEG₆-butyl amine hydrochloride

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(S,R,S)-AHPC-C₆-CO₂H hydrochloride

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5-bromo-naphthalen-1-ylamine

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4,4′-ジ-tert-ブチル-2,2′-ジピリジル

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(S,R,S)-AHPC-PEG₂-butyl CO₂H

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1,1,3,3-テトラメチルグアニジン

Sigma-Aldrich

398594

塩化オスミウム(III)

ligand

VH032

アッセイ

≥95%

形状

solid

反応適合性

reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate

官能基

alkyl halide

保管温度

2-8°C

SMILES記法

ClCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O

アプリケーション

Protein degrader builiding block (S,R,S)-AHPC-C₆-PEG₃-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

その他情報

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

905380-BULK:
905380-VAR:
905380-50MG:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

MKCJ6872

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

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Slide 1 of 6

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(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride

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Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

Ashton C Lai et al.

Angewandte Chemie (International ed. in English), 55(2), 807-810 (2015-11-26)

Proteolysis Targeting Chimera (PROTAC) technology is a rapidly emerging alternative therapeutic strategy with the potential to address many of the challenges currently faced in modern drug development programs. PROTAC technology employs small molecules that recruit target proteins for ubiquitination and

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

Impact of linker length on the activity of PROTACs.

Kedra Cyrus et al.

Molecular bioSystems, 7(2), 359-364 (2010-10-06)

Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations

Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Philipp M Cromm et al.

Cell chemical biology, 24(9), 1181-1190 (2017-06-27)

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can

Targeted Protein Degradation by Small Molecules.

Daniel P Bondeson et al.

Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)

Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of

資料

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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Key Documents

安全性情報

(S,R,S)-AHPC-C6-PEG3-butyl chloride

≥95%

About This Item

おすすめの製品

特性

ligand

アッセイ

形状

反応適合性

官能基

保管温度

SMILES記法

詳細

アプリケーション

その他情報

法的情報

関連製品

関連製品

安全性情報

保管分類コード

WGK

引火点(°F)

引火点(℃)

適用法令

Jan Code

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

この製品を見ている人はこちらもチェック

参考文献

プロトコルと関連資料

資料

テクニカルサービス

(S,R,S)-AHPC-C₆-PEG₃-butyl chloride