901855

(S,R,S)-AHPC-PEG₅-Alkyne

• 別名: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16,19-pentaoxa-3-azadocos-21-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader
• 実験式（ヒル表記法）: C₃₆H₅₂N₄O₉S
• 分子量: 716.88
• MDL番号: MFCD32173799
• UNSPSCコード: 51171641
• NACRES: NA.22

特性

• ligand: VH032
• フォーム: solid
• 反応適合性: reaction type: click chemistry; reagent type: ligand-linker conjugate
• 官能基: alkyne
• 保管温度: 2-8°C
• SMILES記法: O=C(CCOCCOCCOCCOCCOCC#C)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C
• InChI: 1S/C36H52N4O9S/c1-6-12-45-14-16-47-18-20-49-21-19-48-17-15-46-13-11-31(42)39-33(36(3,4)5)35(44)40-24-29(41)22-30(40)34(43)37-23-27-7-9-28(10-8-27)32-26(2)38-25-50-32/h1,7-10,25,29-30,33,41H,11-24H2,2-5H3,(H,37,43)(H,39,42)/t29-,30+,33-/m1/s1
• InChI Key: GNFQUUAQFALSSX-YLJHYDRVSA-N

詳細

アプリケーション

Protein degrader builiding block (S,R,S)-AHPC-PEG₅-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

その他情報

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable