910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• 別名: Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• 実験式（ヒル表記法）: C₁₂H₂₃N₃O₇
• CAS番号: 217180-81-9
• 分子量: 321.33
• MDL番号: MFCD31561141
• UNSPSCコード: 12352106

特性

• アッセイ: ≥95%
• 形状: (Liquid or Semi-solid or Paste or Solid)
• 反応適合性: reaction type: click chemistry; reagent type: cross-linking reagent
• 官能基: azide; carboxylic acid
• 保管温度: 2-8°C
• SMILES記法: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

その他情報

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable