902691

Hydroxy-PEG5-t-butyl ester

• 別名: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• 実験式（ヒル表記法）: C₁₇H₃₄O₈
• CAS番号: 850090-09-4
• 分子量: 366.45
• MDL番号: MFCD20926402
• UNSPSCコード: 51171641

特性

• アッセイ: ≥95%
• 形状: liquid
• 反応適合性: reagent type: cross-linking reagent
• 屈折率: n/D 1.448
• 密度: 1.071
• 官能基: ester; hydroxyl
• 保管温度: −20°C
• SMILES記法: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

その他情報

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable