おすすめの製品
アッセイ
≥95%
フォーム
liquid
反応適合性
reagent type: cross-linking reagent
屈折率
n/D 1.4492
密度
1.04746 g/mL
官能基
ester
hydroxyl
保管温度
2-8°C
SMILES記法
O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
InChI
1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
InChI Key
FJRDXEGYAVAMLB-UHFFFAOYSA-N
関連するカテゴリー
アプリケーション
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
その他情報
法的情報
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
関連製品
製品番号
詳細
価格
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
902586-1G:
902586-BULK:
902586-250MG:
902586-VAR:
最新バージョンのいずれかを選択してください：
Michael L Miller et al.
Journal of medicinal chemistry, 47(20), 4802-4805 (2004-09-17)
To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or C-7 position
Synthesis of novel heterobifunctional isocyanato cross-linkers and their applications for the preparation of 10-hydroxycamptothecin and SN-38 conjugates with melanotransferrin P97.
Li Z, et al.
Synthetic Communications, 37(11) (2007)
Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology.
Mei D, et al
Tetrahedron, 67(12), 2251-2259 (2011)
A new route for the synthesis of 1-amino-3,6,9,12-?tetraoxapentadecan-15-oic acid.
Wu X, et al.
J. Chem. Res. (M), 40(6), 368-370 (2016)
Nico Rublack et al.
Journal of nucleic acids, 2011, 805253-805253 (2011-10-21)
Nowadays, RNA synthesis has become an essential tool not only in the field of molecular biology and medicine, but also in areas like molecular diagnostics and material sciences. Beyond synthetic RNAs for antisense, aptamer, ribozyme, and siRNA technologies, oligoribonucleotides carrying
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）