901567

Propargyl-PEG₁-acid

≥95%

• 実験式（ヒル表記法）: C₆H₈O₃
• CAS番号: 55683-37-9
• 分子量: 128.13
• MDL番号: MFCD10689189
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• アッセイ: ≥95%
• 形状: liquid
• 反応適合性: reagent type: linker
• 官能基: alkyne; carboxylic acid
• 保管温度: −20°C
• SMILES記法: OC(CCOCC#C)=O
• InChI: 1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)
• InChI Key: GMFDYXLFHSFUHE-UHFFFAOYSA-N

詳細

アプリケーション

Propargyl-PEG₁-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₁-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3