902543

Propargyl-PEG4-acid

• 別名: 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• 実験式（ヒル表記法）: C₁₂H₂₀O₆
• CAS番号: 1415800-32-6
• 分子量: 260.28
• MDL番号: MFCD22683284
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• フォーム: liquid
• 反応適合性: reagent type: linker
• 利用可能性: available only in USA
• 屈折率: n/D 1.460
• 密度: 1.164 g/mL
• 官能基: alkyne; carboxylic acid
• 保管温度: −20°C
• SMILES記法: OC(CCOCCOCCOCCOCC#C)=O

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

その他情報

Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• ピクトグラム: GHS02
• シグナルワード: Danger
• 危険有害性情報: H242
• 注意書き: P210 - P234 - P235 - P240 - P370 + P378 - P403
• 危険有害性の分類: Self-react. C
• 保管分類コード: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable