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900865

Sigma-Aldrich

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

Sinônimo(s):

Formyl sulfonyl fluoride TMS-Alkyne, Probe building block

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About This Item

Fórmula empírica (Notação de Hill):
C12H13FO3SSi
Número CAS:
2088829-01-8
Peso molecular:
284.38
Código UNSPSC:
12352200
NACRES:
NA.22

Ensaio

≥95%

Formulário

powder or crystals

adequação da reação

reaction type: click chemistry

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O=CC1=CC=C(S(=O)(F)=O)C(C#C[Si](C)(C)C)=C1

Aplicação

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and aldehyde synthetic handle. When appended to a ligand or pharmacophore through its formyl linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Outras notas

Technology Spotlight: Trifunctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Artigos

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction

In collaboration with K. Barry Sharpless and coworkers, Sigma-Aldrich now offers a variety of sulfonyl fluoride reagents that undergo a “Click II” reaction.

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

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