917133

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

≥95%

• Synonim(y): Semi-flexible linker for PROTAC^® development
• Wzór empiryczny (zapis Hilla): C₁₂H₂₀Cl₂N₂
• Numer CAS: 2140866-85-7
• Masa cząsteczkowa: 263.21
• Numer MDL: MFCD29075588
• Kod UNSPSC: 12352116

Właściwości

• Poziom jakości: 100
• Próba: ≥95%
• Postać: powder
• przydatność reakcji: reagent type: linker
• grupa funkcyjna: amine
• temp. przechowywania: 2-8°C
• ciąg SMILES: NCC1=CC=C(C=C1)C2CCNCC2.Cl.Cl

Opis

Zastosowanie

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Inne uwagi

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable