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916870

Sigma-Aldrich

4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid

≥95%

Synonim(y):

Semi-flexible linker for PROTAC® development

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About This Item

Wzór empiryczny (zapis Hilla):
C17H23NO4
Numer CAS:
149353-75-3
Masa cząsteczkowa:
305.37
Numer MDL:
MFCD02178897
Kod UNSPSC:
12352106

Poziom jakości

100

Próba

≥95%

Formularz

powder

przydatność reakcji

reagent type: linker

grupa funkcyjna

Boc
carboxylic acid

temp. przechowywania

2-8°C

ciąg SMILES

O=C(N(CC1)CCC1C(C=C2)=CC=C2C(O)=O)OC(C)(C)C

InChI

1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-13(9-11-18)12-4-6-14(7-5-12)15(19)20/h4-7,13H,8-11H2,1-3H3,(H,19,20)

Klucz InChI

YCNVQGGUCDVTIZ-UHFFFAOYSA-N

Zastosowanie

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Inne uwagi

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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Piktogramy

Exclamation markEnvironment
GHS07,GHS09

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H315,H317,H319,H410

Zwroty wskazujące środki ostrożności

P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338

Klasyfikacja zagrożeń

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number

Przepraszamy, ale COA dla tego produktu nie jest aktualnie dostępny online.

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