901565

Propargyl-PEG₃-acid

• Wzór empiryczny (zapis Hilla): C₁₀H₁₆O₅
• Numer CAS: 1347760-82-0
• Masa cząsteczkowa: 216.23
• Numer MDL: MFCD22201521
• Kod UNSPSC: 12352106
• NACRES: NA.22

Właściwości

• Formularz: liquid
• przydatność reakcji: reagent type: linker
• grupa funkcyjna: alkyne; carboxylic acid
• temp. przechowywania: −20°C
• ciąg SMILES: C#CCOCCOCCOCCC(O)=O
• Klucz InChI: CJNSWLAJTZVSRB-UHFFFAOYSA-N

Opis

Zastosowanie

Propargyl-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains three PEG units to help improve solubility.

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3