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H4914

Sigma-Aldrich

Honokiol

≥98% (HPLC), powder

Sinônimo(s):

5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100

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About This Item

Fórmula empírica (Notação de Hill):
C18H18O2
Número CAS:
35354-74-6
Peso molecular:
266.33
Número MDL:
MFCD00016674
Código UNSPSC:
12352200
ID de substância PubChem:
24724501
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

condição de armazenamento

desiccated

solubilidade

DMSO: 36 mg/mL

espectro de atividade do antibiótico

Gram-positive bacteria
neoplastics

Modo de ação

DNA synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

chave InChI

FVYXIJYOAGAUQK-UHFFFAOYSA-N

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Descrição geral

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Aplicação

Honokiol has been used:
  • to study its effects on plasmid hSirt3102-399 deacetylation activity
  • as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
  • to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
  • for intracerebroventricular (ICV) cannulation

Ações bioquímicas/fisiológicas

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

CorrosionEnvironment
GHS05,GHS09

Palavra indicadora

Danger

Frases de perigo

H318,H411

Classificações de perigo

Aquatic Chronic 2 - Eye Dam. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
066M4759V
105M4740V
074M4709V
123M4736V
092M4730V

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PHL89315

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Atanas G Atanasov et al.
Biochimica et biophysica acta, 1830(10), 4813-4819 (2013-07-03)
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are clinically used to counteract hyperglycemia. However, so far experienced unwanted side effects, such as weight gain, promote the search for new PPARγ activators. We used a combination of in silico, in vitro, cell-based
The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors
Alexeev M, et al.
Neuropharmacology, 62(8), 2507-2514 (2012)
Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control
Ramirez S, et al.
Cell Metabolism, 25(6), 1390-1399 (2017)
The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease
Liu Y, et al.
PLoS ONE, 8(8), e73173-e73173 (2013)
Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats
Zheng J, et al.
Frontiers in Neuroscience, 12, 526376-526376 (2018)
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Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

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