M3949

MST-312

≥98% (HPLC)

• Sinônimo(s): N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
• Fórmula empírica (Notação de Hill): C₂₀H₁₆N₂O₆
• Número CAS: 368449-04-1
• Peso molecular: 380.35
• Número MDL: MFCD24368986
• Código UNSPSC: 12352200
• ID de substância PubChem: 329817985
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: off-white to light tan
• solubilidade: DMSO: ≥20 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
• InChI: 1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
• chave InChI: MIQUEZGHEJGPJB-UHFFFAOYSA-N

Descrição

Aplicação

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Ações bioquímicas/fisiológicas

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable