08511

Curcumin

analytical standard

• Sinônimo(s): (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
• Fórmula linear: [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
• Número CAS: 458-37-7
• Peso molecular: 368.38
• Número do índice de cores: 75300
• Beilstein: 2306965
• Número CE: 207-280-5
• Número MDL: MFCD00008365
• Código UNSPSC: 85151701
• ID de substância PubChem: 329748594
• Número E: E100
• NACRES: NA.24

Propriedades

• grau: analytical standard
• Nível de qualidade: 100
• densidade de vapor: 13 (vs air)
• Ensaio: ≥98.0% (HPLC)
• Formulário: powder
• prazo de validade: limited shelf life, expiry date on the label
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): cleaning products; cosmetics; food and beverages; personal care
• Formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• InChI: 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
• chave InChI: VFLDPWHFBUODDF-FCXRPNKRSA-N

Descrição

Descrição geral

Curcumin is an anti-inflammatory agent extracted from the roots of Curcuma longa Linn.

Aplicação

Curcumin may be used as a reference standard for the determination of curcumin in rat plasma by high-performance liquid chromatography method.

Ações bioquímicas/fisiológicas

A natural phenolic compound responsible for the yellow color of turmeric. Potent anti-tumor agent that acts against highly diverse tumor-specific pathways. Anti-inflammatory and anti-oxidant. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX).

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

This compound is commonly found in plants of the genus: curcuma

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable