PHL89180

Curcumin

phyproof^® Reference Substance

• Sinônimo(s): (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
• Fórmula linear: [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
• Número CAS: 458-37-7
• Peso molecular: 368.38
• Número do índice de cores: 75300
• Beilstein: 2306965
• Número MDL: MFCD00008365
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: primary reference standard
• densidade de vapor: 13 (vs air)
• linha de produto: phyproof^® Reference Substance
• Ensaio: ≥98.0% (HPLC)
• forma: powder
• fabricante/nome comercial: PhytoLab
• cadeia de caracteres SMILES: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• InChI: 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
• chave InChI: VFLDPWHFBUODDF-FCXRPNKRSA-N

Descrição

Descrição geral

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Ações bioquímicas/fisiológicas

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Outras notas

This compound is commonly found in plants of the genus: curcuma

Informações legais

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable