G6649

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

• Sinônimo(s): 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₅
• Número CAS: 446-72-0
• Peso molecular: 270.24
• Beilstein: 263823
• Número CE: 207-174-9
• Número MDL: MFCD00016952
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278036
• NACRES: NA.77

Propriedades

• product name: Genistein, synthetic, ≥98% (HPLC), powder
• fonte biológica: synthetic
• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: off-white to yellow
• pf: 297.0-298.0 °C
• solubilidade: DMSO: soluble; ethanol: soluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• chave InChI: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• Informações sobre genes: human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100) ; mouse ... Esr1(13982) , Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

Descrição

Descrição geral

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).

Aplicação

Genistein has been used:

• as a test compound to access its estrogeniic acivity
• as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ
• as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes

Ações bioquímicas/fisiológicas

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type N95 (US)