PZ0013

Nelfinavir mesylate hydrate

≥98% (HPLC)

• Sinônimo(s): 3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate, AG-1343, Nelfinavir methanesulfonate hydrate
• Fórmula empírica (Notação de Hill): C₃₂H₄₅N₃O₄S · CH₃SO₃H · xH₂O
• Número CAS: 159989-65-8
• Peso molecular: 663.89 (anhydrous basis)
• Código UNSPSC: 12352200
• ID de substância PubChem: 329823682
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• solubilidade: DMSO: ≥2 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC1=C(O)C=CC=C1C(N[C@@H](CSC2=CC=CC=C2)[C@H](O)CN3[C@H](C(NC(C)(C)C)=O)C[C@@]4([H])[C@@](CCCC4)([H])C3)=O.[CH2]S(O)(=O)=O
• InChI: 1S/C32H45N3O4S.CH4O3S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4;1-5(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39);1H3,(H,2,3,4)/t22-,23+,26-,27-,29+;/m0./s1
• chave InChI: NQHXCOAXSHGTIA-SKXNDZRYSA-N

Descrição

Aplicação

Nelfinavir mesylate hydrate has been used to test its therapeutic effect on pulmonary fibrosis in patients with systemic sclerosis (SSc). It has also been used in combination with bortezomib to selectively kill tuberous sclerosis complex 2 (TSC2)-deficient tumor cells.

Ações bioquímicas/fisiológicas

Nelfinavir mesylate hydrate, also known as AG1343, is used as a therapeutic agent for acquired immunodeficiency syndrome (AIDS). It acts as an antifibrotic agent and is used to treat pulmonary fibrosis in patients with systemic sclerosis (SSc). In addition, nelfinavir mesylate hydrate reduces inflammation by activating protein phosphatase 2 (PP-2) and blocking mitogen-activated protein kinases (MAPK) signaling in macrophages. It also stimulate autophagy and exhibit anti-cancer property.

Nelfinavir is a HIV protease inhibitor; antiretroviral; and anti-tumor agent.

Características e benefícios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable