5.31042

ICI 182,780

≥98% (HPLC), powder, GPR30 agonist, Calbiochem^®

• Sinônimo(s): Estrogen Receptor Antagonist, ICI 182,780, GPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
• Fórmula empírica (Notação de Hill): C₃₂H₄₇F₅O₃S
• Número CAS: 129453-61-8
• Peso molecular: 606.77
• Número MDL: MFCD00903953
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: Estrogen Receptor Antagonist, ICI 182,780,
• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• Formulário: powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 100 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: FC(F)(F)C(F)(F)CCC[S](=O)CCCCCCCCC[C@H]1[C@H]2[C@H]3[C@@]([C@H](CC3)O)(CC[C@@H]2c4c(cc(cc4)O)C1)C
• InChI: 1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
• chave InChI: VWUXBMIQPBEWFH-WCCTWKNTSA-N

Descrição

Descrição geral

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.



Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
ER

Secondary Target
GPR30

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Wakeling, A. E., et al. 1991. Cancer Res.51, 3867.
Dauvois, S., et al. 1993. J. Cell. Sci.106, 1377.
Howell, A., et al. 1995. The Lancet.8941, 29.
Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol.79, 209.

Informações legais

Sold with the permission of AstraZeneca UK. Limited for research purposes only.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Frases de perigo: H413
• Declarações de precaução: P273 - P501
• Classificações de perigo: Aquatic Chronic 4
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3