N3510
Niclosamide
Sinônimo(s):
2′,5-Dichloro-4′-nitrosalicylanilide
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About This Item
Fórmula empírica (Notação de Hill):
C13H8Cl2N2O4
Número CAS:
Peso molecular:
327.12
Beilstein:
2820605
Número CE:
Número MDL:
Código UNSPSC:
51102829
ID de substância PubChem:
NACRES:
NA.85
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Formulário
powder
Nível de qualidade
espectro de atividade do antibiótico
parasites
Modo de ação
enzyme | inhibits
cadeia de caracteres SMILES
Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI
1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
chave InChI
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
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Aplicação
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.
Ações bioquímicas/fisiológicas
Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.
Outras notas
50g,250g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Yanli Jin et al.
Cancer research, 70(6), 2516-2527 (2010-03-11)
NF-kappaB may be a potential therapeutic target for acute myelogenous leukemia (AML) because NF-kappaB activation is found in primitive human AML blast cells. In this report, we initially discovered that the potent antineoplastic effect of niclosamide, a Food and Drug
Mechanism of action of reagents that uncouple oxidative phosphorylation.
E C Weinbach et al.
Nature, 221(5185), 1016-1018 (1969-03-15)
Min Li et al.
The Journal of biological chemistry, 288(50), 35769-35780 (2013-11-01)
Autophagy can be activated via MTORC1 down-regulation by amino acid deprivation and by certain chemicals such as rapamycin, torin, and niclosamide. Lysosome is the degrading machine for autophagy but has also been linked to MTORC1 activation through the Rag/RRAG GTPase
Jones Gyamfi et al.
Scientific reports, 9(1), 11336-11336 (2019-08-07)
The microenvironment of breast cancer comprises predominantly of adipocytes. Adipocytes drive cancer progression through the secretion adipocytokines. Adipocytes induce epithelial mesenchymal transition of breast cancer cells through paracrine IL-6/Stat3 signalling. Treatment approaches that can target adipocytes in the microenvironment and
Yi-Te Yo et al.
Molecular cancer therapeutics, 11(8), 1703-1712 (2012-05-12)
A recent hypothesis for cancer chemoresistance posits that cytotoxic survival of a subpopulation of tumor progenitors drives the propagation of recurrent disease, underscoring the need for new therapeutics that target such primitive cells. To discover such novel compounds active against
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