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70990

Supelco

α-Cyano-4-hydroxycinnamic acid

matrix substance for MALDI-MS, ≥99.0% (HPLC)

Synonim(y):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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About This Item

Wzór liniowy:
HOC6H4CH=C(CN)CO2H
Numer CAS:
28166-41-8
Masa cząsteczkowa:
189.17
Beilstein:
3271427
Numer WE:
248-879-1
Numer MDL:
MFCD00004204
Kod UNSPSC:
12000000
Identyfikator substancji w PubChem:
329762519
NACRES:
NA.21

klasa czystości

matrix substance for MALDI-MS

Poziom jakości

100

Próba

≥99.0% (HPLC)

Postać

solid

klasy chemiczne analitów

glycans, peptides, proteins

metody

MALDI-MS: suitable

mp

245-250 °C (lit.)
245-250 °C

rozpuszczalność

methanol: 10 mg/mL, clear

ślady kationów

Ba: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
K: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤10 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

absorpcja

≥2000 at 337 nm (mol. absorption)

ciąg SMILES

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

Klucz InChI

AFVLVVWMAFSXCK-VMPITWQZSA-N

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Opis ogólny

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is widely used as a matrix in order to facilitate ionization of peptides and proteins in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Zastosowanie

α-CHCA was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

Inne uwagi

Matrix substance used in MALDI-MS (matrix-assisted laser desorption ionization MS) peptide analysis in proteomics.
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Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H317

Zwroty wskazujące środki ostrożności

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Klasyfikacja zagrożeń

Skin Sens. 1B

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
BCCG3811
BCCC8081
BCBZ5249
BCBV7481
BCBQ6945V

Nie widzisz odpowiedniej wersji?

Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

Wyszukaj dokument COA

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

S.D. Patterson, V. Katta
Analytical Chemistry, 66, 3729-3729 (1994)
J Gobom et al.
Analytical chemistry, 73(3), 434-438 (2001-02-24)
We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of
Xiangping Zhu et al.
Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
Alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) as a matrix facilitates the ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. The matrix itself also ionizes and so do its sodium and potassium adducts. Matrix clusters and metal
Martin Winter et al.
SLAS discovery : advancing life sciences R & D, 24(7), 766-777 (2019-05-07)
Microbial-dependent trimethylamine (TMA) generation from dietary precursors such as choline was recently linked to cardiovascular diseases (CVDs) as well as chronic kidney disease (CKD). Inhibition of TMA-generating enzymes in gut bacteria would be an innovative approach to treat these diseases.
Kevser Biberoglu et al.
Biochimica et biophysica acta, 1834(4), 745-753 (2013-01-29)
Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was to determine whether soluble tetrameric AChE includes
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