920541

tert-Butyl 1-oxa-4,9-diazaspiro[5.6]dodecane-9-carboxylate

• Synonim(y): Rigid linker for PROTAC^® development
• Wzór empiryczny (zapis Hilla): C₁₄H₂₆N₂O₃
• Numer CAS: 1779375-54-0
• Masa cząsteczkowa: 270.37
• Numer MDL: MFCD22396643
• Kod UNSPSC: 12352106
• NACRES: NA.22

Właściwości

• Postać: solid
• Poziom jakości: 100
• przydatność reakcji: reagent type: linker
• grupa funkcyjna: Boc
• temp. przechowywania: 2-8°C
• ciąg SMILES: CC(C)(OC(N1CCCC2(CC1)CNCCO2)=O)C

Opis

Zastosowanie

tert-Butyl 1-oxa-4,9-diazaspiro[5.6]dodecane-9-carboxylate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar to CH4979588668

Inne uwagi

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable