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Merck

857128P

Avanti

18:0 Lyso PA

Avanti Research - A Croda Brand

Synonim(y):

1-octadecanoyl-sn-glycero-3-phosphate (sodium salt); stearoyl lysophosphatidic acid; PA(18:0/0:0); 18:0 LPA; s-LPA; 110680

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About This Item

Wzór empiryczny (zapis Hilla):
C21H42O7PNa
Numer CAS:
Masa cząsteczkowa:
460.52
Kod UNSPSC:
51191904
NACRES:
NA.25

opis

1-stearoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

Próba

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

Postać

powder

opakowanie

pkg of 1 × 25 mg (857128P-25mg)

producent / nazwa handlowa

Avanti Research - A Croda Brand

typ lipidu

cardiolipins
phospholipids

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

Opis ogólny

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells. 18:0 Lyso PA has stearic acid at sn-1 and a hydroxyl group at sn-2 position.

Zastosowanie

18:0 Lyso PA is suitable for use:
  • to determine the extraction recovery of LPA at neutral pH and acidic pH by chromatographic method
  • to use as internal standard to study the role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis
  • to investigate its effects on clathrin?dependent endocytosis

Działania biochem./fizjol.

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).

Opakowanie

5 mL Amber Glass Screw Cap Vial (857128P-25mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3


Certyfikaty analizy (CoA)

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Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation, 2017 (2017)
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Ailte I, et al.
Traffic, 18(3), 176-191 (2017)
Mohamad Navab et al.
Journal of lipid research, 54(12), 3403-3418 (2013-10-03)
We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)

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