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857123P

Avanti

16:0 Lyso PA

Avanti Research™ - A Croda Brand

Synonim(y):

1-hexadecanoyl-sn-glycero-3-phosphate (sodium salt); palmitoyl lysophosphatidic acid; PA(16:0/0:0); 16:0 LPA; 110678

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About This Item

Wzór empiryczny (zapis Hilla):
C19H38O7PNa
Numer CAS:
17618-08-5
Masa cząsteczkowa:
432.46
Numer MDL:
MFCD00133396
Kod UNSPSC:
51191904
NACRES:
NA.25

opis

1-palmitoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

Próba

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

Formularz

powder

opakowanie

pkg of 1 × 200 mg (857123P-200mg)
pkg of 1 × 25 mg (857123P-25mg)

producent / nazwa handlowa

Avanti Research™ - A Croda Brand

typ lipidu

phospholipids
cardiolipins

Warunki transportu

dry ice

temp. przechowywania

−20°C

Opis ogólny

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position.

Zastosowanie

16:0 Lyso PA is suitable to use as an internal standard to extract lipids from plasma sample of ovarian cancer patients. It is also suitable for the preparation of lipid solutions for synthesizing liposomes.

Działania biochem./fizjol.

Lysophosphatidic acid (LPA) participates in several biological functions. It acts as a potential biomarker for detecting ovarian cancer. LPA stimulates platelet aggregation, smooth muscle contraction, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization, neurotransmitter release and cell proliferation. Palmitoyl-lysophosphatidic acid helps in increasing aggregation, stimulated by adenosine diphosphate (ADP).

Opakowanie

5 mL Amber Glass Screw Cap Vial (857123P-200mg)
5 mL Amber Glass Screw Cap Vial (857123P-25mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Numer produktu
Opis
Cennik

Kod klasy składowania

11 - Combustible Solids

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Certyfikaty analizy (CoA)

Lot/Batch Number

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The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling
Koprivanacz K, et al.
Cellular Signalling, 32(1-2), 66-75 (2017)
Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets
Benton AM, et al.
Blood, 60(3), 642-649 (1982)
Maya Sawada et al.
Langmuir : the ACS journal of surfaces and colloids, 36(17), 4671-4681 (2020-04-10)
Amyloid fibrils are formed by denatured proteins when the supersaturation of denatured proteins is broken by agitation, such as ultrasonication, or by seeding, although the detailed mechanism of how solubility and supersaturation regulate amyloid formation remains unclear. To further understand
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Qingxin Shi et al.
Food & function, 10(12), 7782-7792 (2019-11-30)
Triterpenoid saponins from Kuding tea have demonstrated preventive effects on hyperlipidaemia induced by a high-fat diet. Lysoglycerophospholipids (Lyso-GPLs) are known to be associated with proatherogenic conditions such as hyperlipidaemia. In this study, a target profiling strategy based on a multiple
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