L7260

Oleoyl-L-α-lysophosphatidic acid sodium salt

≥98%, solid

• Synonim(y): 1-Oleoyl-sn-glycerol 3-phosphate sodium salt, 3-sn-Lysophosphatidic acid, 1-oleoyl sodium salt, LPA sodium salt
• Wzór empiryczny (zapis Hilla): C₂₁H₄₁O₇P · xNa⁺
• Numer CAS: 22556-62-3
• Masa cząsteczkowa: 436.52 (free acid basis)
• Numer MDL: MFCD00133427
• Kod UNSPSC: 12352211
• Identyfikator substancji w PubChem: 24896456
• NACRES: NA.77

Właściwości

• Poziom jakości: 200
• Próba: ≥98%
• Postać: solid
• kolor: white
• typ lipidu: phosphoglycerides
• temp. przechowywania: −20°C
• ciąg SMILES: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C21H41O7P.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);;/b10-9+;;
• Klucz InChI: CHJOEWDRTPWOCY-TTWKNDKESA-N

Opis

Opis ogólny

Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling. Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4. In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.

Zastosowanie

Oleoyl-L-α-lysophosphatidic acid sodium salt has been used:

• for the activation of Ras homolog gene family, member A (RhoA) and expression of claudin-1 in human breast cancer epithelial cell line
• in RH7777 cells for cyclic adenosine monophosphate (cAMP) accumulation assay and calcium mobilisation assay
• in vitro luciferase assay and live-cell imaging

Działania biochem./fizjol.

Endogenous agonist for LPA₁ and LPA₂ receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.

Cechy i korzyści

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Przestroga

Hygroscopic, photosensitive

Uwaga dotycząca przygotowania

Prepared by the action of phospholipase A on L-α-phosphatidic acid, dioleoyl.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)