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Merck

857120P

Avanti

14:0 Lyso PA

1-myristoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder

Synonim(y):

1-tetradecanoyl-sn-glycero-3-phosphate (sodium salt); PA(14:0/0:0); 14:0 LPA; 110677

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About This Item

Wzór empiryczny (zapis Hilla):
C17H34O7PNa
Numer CAS:
Masa cząsteczkowa:
404.41
Kod UNSPSC:
51191904
NACRES:
NA.25

Próba

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

Formularz

powder

opakowanie

pkg of 1 × 25 mg (857120P-25mg)
pkg of 1 × 500 mg (857120P-500mg)

producent / nazwa handlowa

Avanti Research - A Croda Brand 857120P

typ lipidu

phospholipids
cardiolipins

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C17H35O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(19)23-14-16(18)15-24-25(20,21)22;/h16,18H,2-15H2,1H3,(H2,20,21,22);/q;+1/p-1/t16-;/m1./s1

Klucz InChI

HGENTPHNTSLRPB-PKLMIRHRSA-M

Opis ogólny

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position.

Zastosowanie

14:0 Lyso PA is suitable to use as internal standard to spike serum samples for the extraction of serum lipids. It is also suitable to use as standard lipids for extraction of lipids and for quality control in multiple reaction monitoring (MRM) assay.

Działania biochem./fizjol.

Lysophosphatidic acid (LPA) participates in several biological functions. It acts as a potential biomarker for detecting ovarian cancer. LPA stimulates platelet aggregation, smooth muscle contraction, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization, neurotransmitter release and cell proliferation.

Opakowanie

20 mL Clear Glass Screw Cap Vial (857120P-500mg)
5 mL Amber Glass Screw Cap Vial (857120P-25mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Kod klasy składowania

11 - Combustible Solids


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Certyfikaty analizy (CoA)

Lot/Batch Number

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Determination of lysophosphatidic acids by capillary electrophoresis with indirect ultraviolet detection
Chen YL and Xu Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 355-363 (2001)
Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
Li L, et al.
Journal of Chromatography A, 1381(2), 140-148 (2015)
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its

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