T7572
Trombina
400-1000 NIH units/mg protein
Sinônimo(s):
Fator IIa
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About This Item
Produtos recomendados
forma
lyophilized powder
Nível de qualidade
atividade específica
400-1000 NIH units/mg protein
Impurezas
HIV, hepatitis B and hepatitis C, tested negative
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... F2(2147)
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Descrição geral
Lyophilized powder containing sucrose, sodium chloride and Tris.
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects.
Aplicação
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess an innovative flow cytometric approach for small-size platelet microparticles.
Ações bioquímicas/fisiológicas
Protease serina que cliva seletivamente ligações Arg-Gly do fibrinogênio para formar fibrina e fibrinopeptídeos A e B.
Definição da unidade
Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard
Nota de análise
The NIH assay procedure uses 0.2 ml diluted plasma (1:1 with saline) as a substrate and 0.1ml of thrombin sample (stabilized in a 1% buffered albumin solution) based on a modification of the method of Biggs. Only clotting times in the range of 15-25 seconds are used for determining thrombin concentrations.
Outras notas
View more information on thrombin at www.sigma-aldrich.com/enzymeexplorer.
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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An innovative flow cytometric approach for small-size platelet microparticles: influence of calcium.
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Artigos
Thrombin Factor IIa is an endolytic serine protease that selectively cleaves the Arg--Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
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