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Merck
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Key Documents

N7389

Sigma-Aldrich

3-Nitro-L-tyrosine

crystalline

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About This Item

Fórmula linear:
O2NC6H3-4-(OH)CH2CH(NH2)CO2H
Número CAS:
Peso molecular:
226.19
Beilstein:
2813157
Número CE:
Número MDL:
Código UNSPSC:
12352200
eCl@ss:
32160406
ID de substância PubChem:
NACRES:
NA.32

forma

crystalline

pf

233-235 °C (dec.) (lit.)

cadeia de caracteres SMILES

N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O

InChI

1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1

chave InChI

FBTSQILOGYXGMD-LURJTMIESA-N

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Aplicação

3-Nitro-L-tyrosine has been used in:
  • western blot analysis to quantify the nitrotyrosine levels in mice tissue protein
  • Murashige–Skoog medium to treat wild type and mitogen-activated protein kinase 6 (mpk6)-2 mutant seedlings for inferring the connection between nitric oxide (NO) and MPK6 functions in the regulation of mitotic microtubule organization
  • immunocytochemistry

Ações bioquímicas/fisiológicas

3-Nitro-L-tyrosine is an oxidant and cytotoxic agent. 3-Nitrotyrosine serves as a biological marker of proteins modified by nitrogen-free radical species in systemic autoimmunogenic conditions. It is a marker for oxidative damage mediated by peroxynitrite. Nitrotyrosine is associated with VEGF-C expression and lymph node metastasis in breast cancer. 3-Nitrotyrosine is produced due to oxidative/nitrosative stress-mediated chemical modifications such as nitration of proteins, which is observed in lung carcinogenesis.

produto relacionado

Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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