H5653

8-Hydroxy-2′-deoxyguanosine

≥98% (TLC), DNA damage biomaker

• Sinônimo(s): 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
• Fórmula empírica (Notação de Hill): C₁₀H₁₃N₅O₅
• Número CAS: 88847-89-6
• Peso molecular: 283.24
• Número MDL: MFCD00210311
• Código UNSPSC: 12352200
• ID de substância PubChem: 24895702
• NACRES: NA.77

Propriedades

• product name: 8-Hydroxy-2′-deoxyguanosine, ≥98% (TLC)
• Nível de qualidade: 200
• Ensaio: ≥98% (TLC)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
• InChI: 1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
• chave InChI: HCAJQHYUCKICQH-UHFFFAOYSA-N

Descrição

Aplicação

8-Hydroxy-2′-deoxyguanosine has been used:

• as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
• as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
• as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo
• as a standard for LC/MS/MS analysis

Ações bioquímicas/fisiológicas

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)