M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Sinônimo(s):
MPO, Peroxidase, myelo
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About This Item
Número CAS:
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
fonte biológica
human leucocytes
Nível de qualidade
forma
lyophilized powder
atividade específica
≥50 units/mg protein
solubilidade
H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
InChI
1S/H2O3/c1-3-2/h1-2H
chave InChI
JSPLKZUTYZBBKA-UHFFFAOYSA-N
Informações sobre genes
human ... MPO(4353)
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Descrição geral
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Aplicação
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Ações bioquímicas/fisiológicas
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
Outras notas
Lysosomal heme-containing protein.
Definição da unidade
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
forma física
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Nota de análise
Source material tested and found negative for antibody to HIV and for HBSAG.
inibidor
Nº do produto
Descrição
Preços
substrato
Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
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Bergeron Y, et al.
Clinical Microbiology Reviews, 66(3), 912-922 (1998)
Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4.
Crooks SW
The European Respiratory Journal, 15(2), 274-280 (2000)
Michael S Runyon et al.
Thrombosis journal, 8, 3-3 (2010-02-26)
Experimental models of pulmonary embolism (PE) that produce pulmonary hypertension (PH) employ many different methods of inducing acute pulmonary occlusion. Many of these models induce PE with intravenous injection of exogenous impervious objects that may not completely reproduce the physiological
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Myeloperoxidase and cardiovascular disease.
Nicholls SJ and Hazen SL
Arteriosclerosis, Thrombosis, and Vascular Biology, 25(6), 1102-1111 (2005)
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