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S2002

Sigma-Aldrich

Sodium azide

ReagentPlus®, ≥99.5%

Sinônimo(s):

Hydrazoic acid sodium salt

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About This Item

Fórmula linear:
NaN3
Número CAS:
26628-22-8
Peso molecular:
65.01
Número CE:
247-852-1
Número MDL:
MFCD00003536
Código UNSPSC:
12352201
ID de substância PubChem:
24899504
NACRES:
NA.21

fonte biológica

synthetic (inorganic)

Nível de qualidade

200

linha de produto

ReagentPlus®

Ensaio

≥99.5%

forma

powder

condição de armazenamento

(Tightly closed. Dry. Keep in a well-ventilated place. Do not store near acids.)

técnica(s)

cell based assay: suitable
immunohistochemistry: suitable

cor

white

pf

370-425 °C

solubilidade

soluble 65 g/L at 20 °C (completely)

adequação

suitable for chromatography
suitable for derivatization

aplicação(ões)

sample preparation

cadeia de caracteres SMILES

[Na]N=[N+]=[N-]

InChI

1S/N3.Na/c1-3-2;/q-1;+1

chave InChI

PXIPVTKHYLBLMZ-UHFFFAOYSA-N

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Descrição geral

Sodium Azide (NaN3) is a potent inhibitor – a water-soluble crystalline powder that′s odorless. Widely recognized for its versatile applications, it plays a pivotal role across molecular biology, cell culture, and biochemical research. Sodium azide is commonly used as a bacteriostatic preservative in aqueous laboratory reagents and biological fluids. It is also a metabolic inhibitor, which inhibits oxidative phosphorylation. In cell culture, it maintains the integrity of your cell lines by preventing microbial contamination. Its application extends to molecular biology, where it aids in preserving nucleic acids for downstream analysis, ensuring the fidelity of your results.

Aplicação

Baylis-Hillman acetates such as ethyl 2-(acetoxyphenylmethyl)acrylate can undergo nucleophilic displacement by sodium azide in aqueous medium to form ethyl (E)-2-azidomethyl-3-phenylpropenoate.
Sodium azide is suitable for use in histopathology to prepare and store tissue samples. Also used as a component of staining buffer (HEPES buffer) for whole mount immunolabelling.
Catalyst for:

  • Oxidative decarboxylation
  • Michael addition reactions

Reagent for synthesis of
  • Blue fluorescent copolymers
  • Metal phosphonates
  • Arenes via aminations

Ações bioquímicas/fisiológicas

Sodium azide is clinically used as a preservative in diluting fluid for counting red blood cells. It prevents capping and internalization of fluorescent surface-bound antibodies in various scientific applications, including flow cytometry.

Outras notas

For additional information on our range of Biochemicals, please complete this form.

Informações legais

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

Órgãos-alvo

Brain

Perigos de suplementos

EUH032

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
STBK6449
STBK6450
STBK5137
STBK5136
MKCQ1781

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Sodium azide

Nucleophilic displacement by azide and cyanide on Baylis-Hillman acetates in water.
Yadav JS, et al.
Tetrahedron Letters, 46(16), 2761-2763 (2005)
Calcium uptake by rat kidney mitochondria.
DeLuca HF and Engstrom GW.
Proceedings of the National Academy of Sciences of the USA, 47(11), 1744-1750 (1961)
Sodium azide, a bacteriostatic preservative contained in commercially available laboratory reagents, influences the responses of human platelets via the cGMP/PKG/VASP pathway.
Russo I, et al.
Clinical Biochemistry, 41(4), 343-349 (2008)
Xiaohua Sun et al.
Organic letters, 9(22), 4495-4498 (2007-10-04)
A novel intermolecular cross-double-Michael addition between nitro and carbonyl activated olefins has been developed through Lewis base catalysis. The reaction took place with a large group of beta-alkyl nitroalkenes and alpha,beta-unsaturated ketone/esters, producing an allylic nitro compound in good to
Y. Wada, et al.,
Tetrahedron, 65, 1059-1062 (2009)
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