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E7159

Sigma-Aldrich

Exo2

≥98% (HPLC)

Sinônimo(s):

2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol

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About This Item

Fórmula empírica (Notação de Hill):
C18H18N4O2S
Número CAS:
304684-77-3
Peso molecular:
354.43
Número MDL:
MFCD00380179
Código UNSPSC:
12352200
ID de substância PubChem:
329799006
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

yellow

solubilidade

DMSO: >20 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1cc(ccc1O)\C=N\Nc2ncnc3sc4CCCCc4c23

InChI

1S/C18H18N4O2S/c1-24-14-8-11(6-7-13(14)23)9-21-22-17-16-12-4-2-3-5-15(12)25-18(16)20-10-19-17/h6-10,23H,2-5H2,1H3,(H,19,20,22)/b21-9+

chave InChI

VFNUTEMVQGLDAG-ZVBGSRNCSA-N

Ações bioquímicas/fisiológicas

Exo2 acts as a chemical probe of intracellular transport.
Exo2 acts as a chemical probe of intracellular transport. Edxo2 has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but appears more selective.
Exo2 is a bioactive small molecule that activates Golgi-endoplasmic reticulum (ER) fusion in mammals by distorting the Golgi apparatus. It prevents the release of secretory cargo from the ER. Exo2 do not modify the morphology of the trans-Golgi network (TGN). It also inhibits the anterograde movement of vesicular stomatitis virus G (VSV G) glycoprotein, from ER to Golgi.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Sigma-Aldrich

5.09306

Late Endosome Trafficking Inhibitor, EGA

GW4869 ≥90% (NMR)

Sigma-Aldrich

D1692

GW4869

Brefeldina A from Penicillium brefeldianum, Ready Made Solution, 10 mg/mL in DMSO

Sigma-Aldrich

B5936

Brefeldina A

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