Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

D7693

Sigma-Aldrich

Dynasore hydrate

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

Sinônimo(s):

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C18H14N2O4 · xH2O
Número CAS:
1202867-00-2
Peso molecular:
322.31 (anhydrous basis)
Número MDL:
MFCD11045288
Código UNSPSC:
12352200
ID de substância PubChem:
329798784
NACRES:
NA.77

Nome do produto

Dynasore hydrate,

Formulário

powder

Nível de qualidade

100

condição de armazenamento

protect from light

cor

off-white

solubilidade

DMSO: ≥10 mg/mL
H2O: insoluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

chave InChI

FKWZHQSDBMSHTN-ZIOFAICLSA-N

Descrição geral

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Aplicação

Dynasore hydrate has been used:
  • for priming fetal mesenchymal stem/stromal cells (fMSC)
  • in confocal microscopy
  • in wound healing/scratch and tube-formation assay
  • to analyse its effects on Coxsackievirus A9 (CAV9) infection
  • to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
  • in live imaging of cells

Ações bioquímicas/fisiológicas

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Environment
GHS09

Palavra indicadora

Warning

Frases de perigo

H400

Declarações de precaução

P273

Classificações de perigo

Aquatic Acute 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
036M4609V
083M4629V
051M4614V
040M46032
040M46031

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 2

1 of 2

Golgicide A ≥98% (HPLC)

Sigma-Aldrich

G0923

Golgicide A

Amiloride hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

A7410

Amiloride hydrochloride hydrate

Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies
Fischer E, et al
Clinical Cancer Research, clincanres-clinca0644 (2012)
G J Hofmeyr et al.
BJOG : an international journal of obstetrics and gynaecology, 121(8), 951-957 (2014-03-14)
Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in
Tom Kirchhausen et al.
Methods in enzymology, 438, 77-93 (2008-04-17)
The large GTPase dynamin is essential for clathrin-dependent coated-vesicle formation. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a screen of approximately 16,000 compounds for
Dynasore disrupts trafficking of HSV proteins
Mues MB, et al.
Journal of Virology, JVI-00636 (2015)
Richard H Tuligenga et al.
The lancet. Diabetes & endocrinology, 2(3), 228-235 (2014-03-14)
Type 2 diabetes increases the risk for dementia, but whether it affects cognition before old age is unclear. We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline. 5653 participants from
Exibir todos os documentos relacionados

Conteúdo relacionado

Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica