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A5282

Sigma-Aldrich

DL-2-Amino-5-phosphonopentanoic acid

≥98% (TLC), solid, NMDA receptor antagonist

Sinônimo(s):

5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV

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About This Item

Fórmula empírica (Notação de Hill):
C5H12NO5P
Número CAS:
76326-31-3
Peso molecular:
197.13
Beilstein:
2446389
Número MDL:
MFCD00010515
Código UNSPSC:
12352106
ID de substância PubChem:
24277950
NACRES:
NA.32

product name

DL-2-Amino-5-phosphonopentanoic acid, solid

forma

solid

cor

white

solubilidade

0.1 M NaOH: 4 mg/mL
H2O: 5.6 mg/mL
organic solvents: insoluble

cadeia de caracteres SMILES

NC(CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)

chave InChI

VOROEQBFPPIACJ-UHFFFAOYSA-N

Informações sobre genes

rat ... Grik1(29559) , Grin2a(24409) , Grin2b(24410)

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Aplicação

DL-2-Amino-5-phosphonopentanoic acid has been used:
  • in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
  • used in growth medium for inhibition of electrical activity in the neuronal network
  • used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
  • used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

Ações bioquímicas/fisiológicas

Anticonvulsant; potent and selective NMDA receptor antagonist.

Atenção

Hygroscopic

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
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