5.04914

CNQX

• Sinônimo(s): CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
• Fórmula empírica (Notação de Hill): C₉H₄N₄O₄
• Número CAS: 115066-14-3
• Peso molecular: 232.15
• Número MDL: MFCD00069232
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white to yellow
• solubilidade: DMSO: 25 mg/mL
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
• chave InChI: RPXVIAFEQBNEAX-UHFFFAOYSA-N

Descrição

Descrição geral

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Ações bioquímicas/fisiológicas

Secondary Target
Kainate

Target K_i: 0.6 – 2.11 →M for GluA1 – 4 and Ki

Advertência

Toxicity: Standard Handling (A)

Outras notas

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
King, A., et al. 1992. Br. J. Pharmacol.107, 375.
Long, S. et al. 1990. Br. J. Pharmacol.100, 850.Harris, K., et al. 1989. Brain Res.5, 185Honore, T., et al. 1988. Science.241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol.156, 177.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable