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C127

Sigma-Aldrich

CNQX

≥98% (HPLC), solid

Sinônimo(s):

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

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About This Item

Fórmula empírica (Notação de Hill):
C9H4N4O4
Número CAS:
115066-14-3
Peso molecular:
232.15
Número MDL:
MFCD00069232
Código UNSPSC:
12352200
ID de substância PubChem:
24892392
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

condição de armazenamento

protect from light

cor

yellow

solubilidade

DMSO: >10 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

chave InChI

RPXVIAFEQBNEAX-UHFFFAOYSA-N

Informações sobre genes

rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409)

Aplicação

CNQX has been used:
  • as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
  • glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
  • as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Ações bioquímicas/fisiológicas

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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CGP 55845 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0594

CGP 55845 hydrochloride

(+)-Bicuculline ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicuculline

(+)-Bicuculline phyproof® Reference Substance

PHL80371

(+)-Bicuculline

1(S),9(R)-(−)-Bicuculline methiodide ≥95.0% (HPCE)

Sigma-Aldrich

14343

1(S),9(R)-(−)-Bicuculline methiodide

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Molecular neurobiology, 56(9), 6436-6450 (2019-03-04)
Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
Julia Pose-Utrilla et al.
Nature communications, 8(1), 2275-2275 (2017-12-24)
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we find
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