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901860

(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride

Name: (S,R,S)-AHPC-PEG6-NH2 hydrochloride
Brand: ALDRICH

≥95%

同義詞:

(2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate

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About This Item

經驗公式（希爾表示法）:

C₃₆H₅₈ClN₅O₁₀S

分子量：:

788.39

分類程式碼代碼:

12352101

NACRES:

NA.22

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901493

(S,R,S)-AHPC-PEG₁-NH₂ hydrochloride

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(S,R,S)-AHPC-PEG₂-NH₂ hydrochloride

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901831

Pomalidomide-PEG₅-NH₂hydrochloride

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(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride

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(S,R,S)-AHPC hydrochloride

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(S,R,S)-AHPC-PEG₄-NH₂ hydrochloride

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901565

Propargyl-PEG₃-acid

ligand

VH032

化驗

≥95%

形狀

powder or crystals

反應適用性

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

官能基

amine

儲存溫度

2-8°C

SMILES 字串

O=C(COCCOCCOCCOCCOCCOCCN)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl

應用

Protein degrader building block (S,R,S)-AHPC-PEG₆-NH₂ (HCL salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他說明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

訊號詞

Warning

危險聲明

H302,H315,H319

防範說明

P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

MKCH3419

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Small-Molecule PROTACS: New Approaches to Protein Degradation.

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Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

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文章

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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Key Documents

(S,R,S)-AHPC-PEG6-NH2 hydrochloride

≥95%

About This Item

推薦產品

屬性

ligand

化驗

形狀

反應適用性

官能基

儲存溫度

SMILES 字串

相關類別

描述

應用

其他說明

法律資訊

相關產品

相關產品

(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride