推薦產品
形狀
liquid
反應適用性
reagent type: linker
存貨情形
available only in USA
折射率
n/D 1.460
密度
1.164 g/mL
官能基
alkyne
carboxylic acid
儲存溫度
−20°C
SMILES 字串
OC(CCOCCOCCOCCOCC#C)=O
應用
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
其他說明
法律資訊
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
相關產品
產品號碼
描述
訂價
訊號詞
Danger
危險聲明
危險分類
Self-react. C
儲存類別代碼
5.2 - Organic peroxides and self-reacting hazardous materials
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants.
Archiv der Pharmazie, 348(10), 689-703 (2015-09-04)
A Cu-mediated azide-alkyne click chemistry protocol was employed for the synthesis of a focused library of novel 1,2,3-triazolyl conjugates bearing various carbohydrate-steroid/triterpenoid entities. The immunogenicity of these compounds was examined initially by ex vivo assays. The lead compound 15g was
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