全部照片(1)

Key Documents

View All Documentation

905216

(S,R,S)-AHPC-PEG₂-butyl azide

Name: (S,R,S)-AHPC-PEG2-butyl azide
Brand: ALDRICH

≥95%

同義詞:

(2S,4R)-1-((S)-2-(2-(2-((6-Azidohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-2-2-6-N3, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate

登入查看組織和合約定價

全部照片(1)

About This Item

經驗公式（希爾表示法）:

C₃₂H₄₇N₇O₆S

分子量：:

657.82

分類程式碼代碼:

51171641

推薦產品

Slide 1 of 10

1 of 10

Sigma-Aldrich

904651

(S,R,S)-AHPC-PEG₃-azide

Sigma-Aldrich

909378

(S,R,S)-AHPC-PEG₆-Azide

Sigma-Aldrich

904864

(S,R,S)-AHPC-PEG₆-butyl azide

Sigma-Aldrich

612200-M

组织纤溶酶原激活物，人

Sigma-Aldrich

T0831

组织纤溶酶原激活剂人

Sigma-Aldrich

755885

聚氨酯丙烯酸酯甲基丙烯酸酯树脂

Sigma-Aldrich

903957

(S,R,S)-AHPC-PEG1-azide

Z805866

Hellma^® cuvettes for special application, Large cells

Z805750

Hellma^® cuvettes for special application, Large cells

Sigma-Aldrich

517941

聚(丙烯腈-co-丙烯酸甲酯)

ligand

VH032

化驗

≥95%

形狀

liquid

反應適用性

reaction type: click chemistry
reagent type: ligand-linker conjugate

官能基

azide

儲存溫度

2-8°C

SMILES 字串

O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)COCCOCCCCCCN=[N+]=[N-]

應用

Protein degrader builiding block (S,R,S)-AHPC-PEG₂-Butyl Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他說明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

抱歉，我們目前沒有在線上提供本產品的COA

如果您需要協助，請聯絡客戶支援

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Momar Toure et al.

Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

Impact of linker length on the activity of PROTACs.

Kedra Cyrus et al.

Molecular bioSystems, 7(2), 359-364 (2010-10-06)

Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations

Targeted Protein Degradation: from Chemical Biology to Drug Discovery.

Philipp M Cromm et al.

Cell chemical biology, 24(9), 1181-1190 (2017-06-27)

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can

Targeted Protein Degradation by Small Molecules.

Daniel P Bondeson et al.

Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)

Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of

文章

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務

Key Documents

(S,R,S)-AHPC-PEG2-butyl azide

≥95%

About This Item

推薦產品

屬性

ligand

化驗

形狀

反應適用性

官能基

儲存溫度

SMILES 字串

描述

應用

其他說明

法律資訊

相關產品

相關產品

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析證明 (COA)

已經擁有該產品？

同儕審查論文

條款與法條

文章

技術服務

(S,R,S)-AHPC-PEG₂-butyl azide