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901830

Pomalidomide-PEG₄-NH₂ hydrochloride

Name: Pomalidomide-PEG<SUB>4</SUB>-NH<SUB>2</SUB> hydrochloride
Brand: ALDRICH

≥95%

同義詞:

14-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader

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About This Item

經驗公式（希爾表示法）:

C₂₃H₃₁ClN₄O₉

分子量：:

542.97

MDL號碼:

MFCD32173792

分類程式碼代碼:

12352101

NACRES:

NA.22

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901495

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(S,R,S)-AHPC hydrochloride

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VH298

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N-(4-Bromophenyl)-N-phenylacrylamide

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来那度胺

Sigma-Aldrich

918091

Lenalidomide-Photoswitch2-NH₂ hydrochloride

ligand

pomalidomide

化驗

≥95%

形狀

powder or crystals

mp

98-109 °C

儲存溫度

2-8°C

SMILES 字串

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCN)=O)=O)NC1=O.Cl

InChI 密鑰

HFCHLXYVKQEGTC-UHFFFAOYSA-N

應用

Protein degrader builiding block Pomalidomide-PEG₄-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他說明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

MKCL1097

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Small-Molecule PROTACS: New Approaches to Protein Degradation.

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Kedra Cyrus et al.

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Conventional genetic approaches have provided a powerful tool in the study of proteins. However, these techniques often preclude selective manipulation of temporal and spatial protein functions, which is crucial for the investigation of dynamic cellular processes. To overcome these limitations

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Philipp M Cromm et al.

Cell chemical biology, 24(9), 1181-1190 (2017-06-27)

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can

Targeted Protein Degradation by Small Molecules.

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Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)

Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of

文章

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Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Partial PROTACs for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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Pomalidomide-PEG4-NH2 hydrochloride

≥95%

About This Item

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屬性

ligand

化驗

形狀

mp

儲存溫度

SMILES 字串

InChI 密鑰

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描述

應用

其他說明

法律資訊

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安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

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Pomalidomide-PEG₄-NH₂ hydrochloride