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901531

Pomalidomide-PEG₃-Alkyne

Name: Pomalidomide-PEG<SUB>3</SUB>-Alkyne
Brand: ALDRICH

≥95%

同義詞:

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanamide, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader

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About This Item

經驗公式（希爾表示法）:

C₂₃H₂₅N₃O₈

分子量：:

471.46

分類程式碼代碼:

51171641

NACRES:

NA.22

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ligand

pomalidomide

品質等級

100

化驗

≥95%

形狀

powder or crystals

反應適用性

reaction type: click chemistry
reagent type: ligand-linker conjugate

官能基

alkyne

儲存溫度

2-8°C

SMILES 字串

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCCOCC#C)=O)=O)NC1=O

應用

Protein degrader builiding block Pomalidomide-PEG3-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他說明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to ProteinDegradation

Targeted Protein Degradation: from ChemicalBiology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of

文章

Degrader Building Blocks for Targeted Protein Degradation

Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Partial PROTACs for Targeted Protein Degradation

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Partial PROTACs for Targeted Protein Degradation

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Degrader Building Blocks for Targeted Protein Degradation

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Key Documents

Pomalidomide-PEG3-Alkyne

≥95%

About This Item

推薦產品

屬性

ligand

品質等級

化驗

形狀

反應適用性

官能基

儲存溫度

SMILES 字串

相關類別

描述

應用

其他說明

法律資訊

相關產品

相關產品

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析證明 (COA)

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Pomalidomide-PEG₃-Alkyne