911747

C5 Lenalidomide-PEG₃-NH₂ hydrochloride

≥95%

• 同義詞: 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide hydrochloride, C5 Lenalidomide conjugate, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader
• 經驗公式（希爾表示法）: C₂₁H₂₈N₄O₇ · xHCl
• 分子量：: 448.47 (free base basis)
• 分類程式碼代碼: 12352101

屬性

• ligand: C5 Lenalidomide
• 化驗: ≥95%
• 形狀: powder or crystals
• 反應適用性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 官能基: amine
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCN)=O)=CC=C31.Cl

描述

應用

Protein degrader builiding block C5 Lenalidomide-PEG₃-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector and a PEGylated crosslinker with pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands, warheads, and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他說明

Degrader Building Blocks for Targeted Protein Degradation.

Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361d,H373
• 防範說明: P201 - P308 + P313
• 危險分類: Repr. 2 - STOT RE 2
• 標靶器官: Blood
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable